报告题目：Organelle Biogenesis and Function in Plants
报 告 人：姜里文 教授
主 持 人：赵琼 研究员
报告时间：2023年11月01日 15：00-16：00
报告地点：闵行校区生命科学学院534小会议室
报告人简介：
姜里文教授，1984年于华南农业大学获学士学位；1992年于University of British Columbia获硕士学位；1996年获得Simon Fraser University博士学位；2000年开始任香港中文大学生物系助理教授；现任香港中文大学生命科学学院卓敏讲席教授、细胞与发育生物学中心主任。同时，现在是Plant Cell 等多个刊物的副主编或编委。主要研究方向是蛋白质的定位和转运、植物细胞内吞和胞吐、细胞器动力学与生物发生；在PNAS、Nature Communication、 Nature Plants、Plant Cell、Molecular Plant、Autophagy、Trends in Plant Science等期刊发表了近百篇有影响力的学术论文。姜教授多次荣获中大理学院模范教学奖、中大优秀科研成果奖、国家教育部高等学校科学研究优秀成果奖、中大理学院杰出学人及中大卓敏生命科学教授席等教学与科研奖。
报告简介：
Membrane trafficking and organelle biogenesis play important roles in regulating plant growth and development, as well as responses to external signals. The plant endomembrane system contains several functionally distinct membrane-enclosed organelles, including the endoplasmic reticulum (ER), Golgi apparatus, trans-Golgi network (TGN) or early endosomes (EE), prevacuolar compartment (PVC) or multivesicular body (MVB) and vacuole. The endosomal sorting complex required for transport (ESCRT) machinery mediates the formation of intraluminal vesicles (ILVs) in MVBs as well as the sorting of the ubiquitinated cargoes into the internal vesicles (ILVs) in eukaryotes. Since 2014, we have characterized a plant unique ESCRT component termed FYVE domain protein required for endosomal sorting 1 (FREE1) and demonstrated that FEFF1 plays multiple functions with distinct underlying mechanisms in plants, including regulation of MVB and vacuole formation (Current Biology 2014), crosstalk between the endomembrane system and the autophagic pathway (PNAS 2015), Abscisic Acid (ABA) signaling (Nature Plants 2019; 2021), degradation of lipid droplets (LDs) in germinating seedlings (Plant Cell 2022), and autophagosome closure under stress condition (Nature Communications 2023). We have also identified and characterized several Arabidopsis sof (suppressor of free1) as novel regulators of the MVB pathway (Nature Communications 2018; Plant Cell 2019; Plant Cell 2023). In this talk, I will summarize our major findings and present an update on our research progress of the multi-functions of FREE1 in regulating organelle biogenesis and function in plants. Supported by Research Grants Council of Hong Kong and CUHK.
